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Frequently Asked Questions for Pharmacists on UNC Hospitals Mucositis Mixture ("Sleepy Butter")

Q: What is the formulation for UNC Hospitals Mucositis Mixture, also known as “Sleepy Butter”?

A: UNC Hospitals Mucositis Mixture has been officially added to the UNC formulary. The approved recipe by the Pharmacy and Therapeutics Committee is:

-Diphenhydramine liquid 2.5 mg/mL
-Maalox suspension (or formulary equivalent)
-Lidocaine, viscous 2%

Admix equal volumes of the three ingredients. UNC usually dispenses 300 mL total volume (6 month expiration).

Recently, UNC discovered a prescription product from CutisPharma, which is a similar formula, but available in a kit (First™ Mouthwash BLM (NDC 65628-050-01)). The kit includes a 236 mL bottle of aluminum hydroxide/magnesium hydroxide/simethicone suspension with two separate bottles, one containing diphenhydramine 0.2 g powder, and the other containing lidocaine hydrochloride powder 1.6 g. The pharmacist can combine the dry powders into the suspension.

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